Single-Cell Immune Repertoire

Linking cell state to immune clones

Joint profiling of single-cell gene expression and TCR/BCR clonotypes to decode immune response across cell state and receptor.

From Single Cell to Expression & Clonotype

Build gene expression and immune repertoire libraries separately via single-cell capture and molecular tagging, then analyze jointly.

Obtain a qualified single-cell suspension

Capture single-cell 5' gene expressionCapture TCR/BCR receptor sequences and clonotypes

Reverse transcription, amplification, library prep and sequencing

Link cell type, expression state and clonotype

用于快速完成数万单细胞的5'转录组文库构建和TCR&BCR文库构建

完成单细胞捕获与分子标记。

完成基因表达与免疫组库数据分析。

Resolve clonal expansion and state shifts of tumor-infiltrating immune cells, uncovering response mechanisms in the TME.

Link autoreactive T/B cell clonotypes to disease, offering clues for autoimmune mechanism research.

Track clonal expansion and response dynamics of pathogen-specific immune cells to understand immune evolution.

Assess clonotype diversity and memory formation induced by vaccines to support evaluation and optimization.

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